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AKA-379
Bempedoic acid
Cat. No.
AKA-379
CAS No.
738606-46-7
MF
C19H36O5
MW
344.49
Bempedoic acid is an ATP-citrate lyase (ACL) inhibitor,activates AMPK.
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Description
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References
Product Name
Bempedoic acid
Chemical name
8-Hydroxy-2,2,14,14-tetramethylpentadecanedioic acid
CAS No.
738606-46-7
MF
C19H36O5
MW
344.49
Specification
98%-102%
Description
Bempedoic acid is an ATP-citrate lyase (ACL) inhibitor,activates AMPK. Packing: 500g/bag，1kg/bag，5kg/bag Availability: In stock API Current Development Status: A3---Process Development / Scale-Up Reference: Aktin major API development processes: A1.Feasibility / Route Development A2.Laboratory Process Development A3.Process Development / Scale-Up A4.GMP Clinical Development A5.Commercial GMP Supply
Documents
-
Specification sheet
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For Certificate of Analysis (COA), Safety Data Sheet (SDS/MSDS) etc., please enquiry by email: info@aktin.com
Storage and Shipping
Avoid light. Store in a sealed container.
References
[1]. Pinkosky SL, et al. AMP-activated protein kinase and ATP-citrate lyase are two distinct molecular targets for ETC-1002, a novel small molecule regulator of lipid and carbohydrate metabolism. J Lipid Res. 2013 Jan;54(1):134-51.
[2]. Filippov S, et al. ETC-1002 regulates immune response, leukocyte homing, and adipose tissue inflammation via LKB1-dependent activation of macrophage AMPK. J Lipid Res. 2013 Aug;54(8):2095-108.
[3].Pinkosky SL, Newton RS, Day EA, Ford RJ, Lhotak S, Austin RC, et al. Liver-specific ATP-citrate lyase inhibition by bempedoic acid decreases LDL-C and attenuates atherosclerosis. Nat Commun. 2016;7:13457.
[4].Ray KK, Bays HE, Catapano AL, Lalwani ND, Bloedon LT, Sterling LR, et al. Safety and efficacy of bempedoic acid to reduce LDL cholesterol. N Engl J Med. 2019;380(11):1022-1032.
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